Thursday, November 21, 2013

Nuts, aspirin, coffee. All good for us. Why?

Certainly a birthday
Probably early 80s
I had more hair and less stomach than I do now.
She was as beautiful as ever
 

Amazing how quickly some news items get around!  There is a new paper by Dr. Ying Bao  (and six others) in the New England Journal of Medicine.  It is about nuts: apparently they help you stay alive.   
In the last 24 hours I have heard about this study on TV (once), radio (twice), and read about it in two newspapers.  Contrast this with the cancer-sniffing-dogs story that broke in early September on “Sixty Minutes”, of all places, but has just now made it to the NY Times.  Maybe the Times was saving it for a slow-news day?  Anyway:
 
The nut result falls out of two massive studies, conducted on medical professionals, which lasted for a long time.  After “controlling” for potential confounding factors, nut-eaters appeared to die less (at any given age, of course; we all die eventually) than do non nut-eaters.  Die of things like cancer and heart disease, that is – people who only eat nuts while driving at high speeds on the freeway probably gain no overall benefit.  The question of “why” doesn’t seem to have a definite answer as yet; there was some mention of reducing cholesterol (heart) and inflammation (cancer), but a detailed explanation was lacking.  The result apparently is robust statistically; although maybe we should get Dr. Ioannidis involved.  Moreover, it was reassuringly dose-dependent: the more nuts you ate, the less likely you were to die.  So, pass the nut bowl.
 
As you can imagine, there are many “confounding factors”.  That is, maybe the cause and effect chain only carries nuts along for the ride.  To make up a stupid example:  When I drink beer with my buddies I often eat nuts.  I don’t doubt that there are many more beer-drinkers  like me.  So, maybe it is the beer that reduces mortality.  Or, to make it even more absurd, note that many people who drink beer drink too much, get a headache, then take aspirin.  It has been shown that aspirin is effective against some cancers, and also thins the blood, hence helps with stroke.  So maybe it’s the aspirin that goes along with the beer and accompanies the nuts that deserves the credit.  These are the sort of things that need to be "controlled" for.  Again, calling Dr. Ioannidis.
 
One disturbing aspect of this study is that it was partially funded by the United Nut Pickers of the World, or some such body.  It is stated that they had no hand in the design of the experiment  nor interpretation of the results.  I’m sure that’s true – isn’t it?
 
Here are the links:
 
 
 
 
 


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